Maintenance treatment of depression in old age: a randomized, double-blind, placebo-controlled evaluation of the efficacy and safety of donepezil combined with antidepressant pharmacotherapy.

ABSTRACT:

Context

Cognitive impairment in late-life depression is a core feature of the illness.

Objective

To test whether donepezil hydrochloride and antidepressant therapy is superior to placebo and antidepressant therapy in improving cognitive performance and instrumental activities of daily living and in reducing recurrences of depression over 2 years of maintenance treatment.

Design

Randomized, double-blind, placebo-controlled maintenance trial.

Setting

University clinic.

Participants

One hundred thirty older adults aged 65 years and older with recently remitted major depression.

Interventions

Random assignment to maintenance antidepressant pharmacotherapy and donepezil or to maintenance antidepressant pharmacotherapy and placebo.

Main outcome measu

SUBMITTER: Reynolds CF 

PROVIDER: S-EPMC3076045 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature