Ontology highlight
ABSTRACT:
SUBMITTER: Guryanova OA
PROVIDER: S-EPMC3076106 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Cancer cell 20110401 4
Glioblastomas display cellular hierarchies containing tumor-propagating glioblastoma stem cells (GSCs). STAT3 is a critical signaling node in GSC maintenance but molecular mechanisms underlying STAT3 activation in GSCs are poorly defined. Here we demonstrate that the bone marrow X-linked (BMX) nonreceptor tyrosine kinase activates STAT3 signaling to maintain self-renewal and tumorigenic potential of GSCs. BMX is differentially expressed in GSCs relative to nonstem cancer cells and neural progeni ...[more]