Biphasic electrical currents stimulation promotes both proliferation and differentiation of fetal neural stem cells.

ABSTRACT: The use of non-chemical methods to differentiate stem cells has attracted researchers from multiple disciplines, including the engineering and the biomedical fields. No doubt, growth factor based methods are still the most dominant of achieving some level of proliferation and differentiation control--however, chemical based methods are still limited by the quality, source, and amount of the utilized reagents. Well-defined non-chemical methods to differentiate stem cells allow stem cell scientists to control stem cell biology by precisely administering the pre-defined parameters, whether they are structural cues, substrate stiffness, or in the form of current flow. We have developed a culture system that allows normal stem cell growth and the option of applying continuous and defined levels

SUBMITTER: Chang KA 

PROVIDER: S-EPMC3076442 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature