Quantification of regional myocardial oxygenation by magnetic resonance imaging: validation with positron emission tomography.

ABSTRACT:

Background

A comprehensive evaluation of myocardial ischemia requires measures of both oxygen supply and demand. Positron emission tomography (PET) is currently the gold standard for such evaluations, but its use is limited because of its ionizing radiation, limited availability, and high cost. A cardiac MRI method was developed for assessing myocardial oxygenation. The purpose of this study was to evaluate and validate this technique compared with PET during pharmacological stress in a canine model of coronary artery stenosis.

Methods and results

Twenty-one beagles and small mongrel dogs without coronary artery stenosis (controls) or with moderate to severe acute coronary artery stenosis underwent MRI and PET imaging at rest and during dipyridamole vasodilation or dobutamin

SUBMITTER: McCommis KS 

PROVIDER: S-EPMC3076677 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature