Androgen receptor expression and breast cancer survival in postmenopausal women.

ABSTRACT:

Purpose

Androgen receptor (AR) is commonly expressed in breast cancers. However, the association between tumor AR status and breast cancer survival is uncertain. Hence, we examined the association between AR status and breast cancer survival in the Nurses' Health Study (NHS).

Experimental design

It was a prospective study of postmenopausal women enrolled in the Nurses' Health Study with stage I to III breast cancer diagnosed between 1976 and 1997 and followed from the date of diagnosis until January 1, 2008 or death. Analyses were conducted using Kaplan-Meier methods and Cox proportional hazard models, to determine the association of AR status with survival outcomes adjusting for covariates.

Results

Among 1467 breast cancers, 78.7% were AR-positive (AR+). Among 1,164

SUBMITTER: Hu R 

PROVIDER: S-EPMC3076683 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature