Microarray assessment of the influence of the conceptus on gene expression in the mouse uterus during decidualization.

ABSTRACT: During pregnancy in several species including humans and rodents, the endometrium undergoes decidualization. This process of differentiation from endometrial to decidual tissue occurs only after the onset of implantation in mice. It can also be artificially induced causing the formation of deciduomal tissue. The purpose of this study was to compare the gene expression profile of the developing decidua in pregnant mice with the deciduoma formed after artificial induction in an effort to identify conceptus-influenced changes in uterine gene expression during decidualization. We induced decidualization artificially by transferring blastocyst-sized ConA-coated agarose beads into the uterus on day 2.5 of pseudopregnancy. Recently published work has found this model to be more 'physiological' th

SUBMITTER: McConaha ME 

PROVIDER: S-EPMC3076716 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature