Propofol-fentanyl versus propofol alone for lumbar puncture sedation in children with acute hematologic malignancies: propofol dosing and adverse events.

ABSTRACT:

Objective

We sought to determine whether the combination of propofol and fentanyl results in lower propofol doses and fewer adverse cardiopulmonary events than propofol and placebo for lumbar puncture in children with acute hematologic malignancies.

Design

Randomized, controlled, double blind, crossover study.

Setting

Pediatric Sedation Program.

Patients

Children with acute leukemia or lymphoma receiving sedation for lumbar puncture.

Interventions

Each patient received two sedations in random order, one with propofol/placebo and one with propofol/fentanyl. The study investigator and patient/parent were blinded to placebo or fentanyl. Data collected included patient age and diagnosis, propofol dose and adverse events. Adverse events included oxygen satura

SUBMITTER: Hollman GA 

PROVIDER: S-EPMC3076743 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature