Transcriptome analysis of chlamydial growth during IFN-gamma-mediated persistence and reactivation.

ABSTRACT: Chlamydia trachomatis is an obligatory intracellular prokaryotic parasite that causes a spectrum of clinically important chronic inflammatory diseases of humans. Persistent infection may play a role in the pathophysiology of chlamydial disease. Here we describe the chlamydial transcriptome in an in vitro model of IFN-gamma-mediated persistence and reactivation from persistence. Tryptophan utilization, DNA repair and recombination, phospholipid utilization, protein translation, and general stress genes were up-regulated during persistence. Down-regulated genes included chlamydial late genes and genes involved in proteolysis, peptide transport, and cell division. Persistence was characterized by altered but active biosynthetic processes and continued replication of the chromosome. On removal

SUBMITTER: Belland RJ 

PROVIDER: S-EPMC307677 | biostudies-literature | 2003 Dec

REPOSITORIES: biostudies-literature