Genetic variation and association analyses of NEDD4 gene in Kazak Chinese patients with hypertension.

ABSTRACT: To analyze the association between the genetic variations of neural precursor cell expressed developmentally down-regulated 4 gene (NEDD4) and hypertension in Kazakh Chinese. The sequences of NEDD4 gene exons were sequenced in 96 Kazakh Chinese with hypertension to identify representative variations. A case-control study was conducted by genotyping the representative variations in 287 Kazakh hypertensives and 411 normotensives. Replication population was 343 Uygur hypertensives and 724 normotensives. All subjects were selected from population-based cross-sectional studies of metabolic disease. Thirteen novel and 15 known single nucleotide polymorphism (SNPs) or mutations, including 6 missense mutations, were identified. Of the four representative SNPs geno-typed, only rs2303580 was associa

SUBMITTER: Li N 

PROVIDER: S-EPMC3076774 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature