CD34 Antigen: Determination of Specific Sites of Phosphorylation In Vitro and In Vivo.

ABSTRACT: CD34, a type I transmembrane glycoprotein, is a surface antigen which is expressed on several cell types, including hematopoietic progenitors, endothelial cells, as well as mast cells. Recently, CD34 has been described as a marker for epidermal stem cells in mouse hair follicles, and is expressed in outer root sheath cells of the human hair follicle. Although the biological function and regulation of CD34 is not well understood, it is thought to be involved in cell adhesion as well as possibly having a role in signal transduction. In addition, CD34 was shown to be critical for skin tumor development in mice, although the exact mechanism remains unknown.Many proteins' functions and biological activities are regulated through post-translational modifications. The extracellular domain of CD34

SUBMITTER: Deterding LJ 

PROVIDER: S-EPMC3077033 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature