Effect of modafinil on learning and task-related brain activity in methamphetamine-dependent and healthy individuals.

ABSTRACT: Methamphetamine (MA)-dependent individuals exhibit deficits in cognition and prefrontal cortical function. Therefore, medications that improve cognition in these subjects may improve the success of therapy for their addiction, especially when cognitive behavioral therapies are used. Modafinil has been shown to improve cognitive performance in neuropsychiatric patients and healthy volunteers. We therefore conducted a randomized, double-blind, placebo-controlled, cross-over study, using functional magnetic resonance imaging, to examine the effects of modafinil on learning and neural activity related to cognitive function in abstinent, MA-dependent, and healthy control participants. Modafinil (200 mg) and placebo were administered orally (one single dose each), in counterbalanced fashion, 2 h

SUBMITTER: Ghahremani DG 

PROVIDER: S-EPMC3077264 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature