Early growth response gene-2 (Egr-2) regulates the development of B and T cells.

ABSTRACT:

Background

Understanding of how transcription factors are involved in lymphocyte development still remains a challenge. It has been shown that Egr-2 deficiency results in impaired NKT cell development and defective positive selection of T cells. Here we investigated the development of T, B and NKT cells in Egr-2 transgenic mice and the roles in the regulation of distinct stages of B and T cell development.

Methods and findings

The expression of Egr1, 2 and 3 were analysed at different stages of T and B cell development by RT-PCT and results showed that the expression was strictly regulated at different stages. Forced expression of Egr-2 in CD2(+) lymphocytes resulted in a severe reduction of CD4(+)CD8(+) (DP) cells in thymus and pro-B cells in bone marrow, which was associat

SUBMITTER: Li S 

PROVIDER: S-EPMC3077377 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature