Variable pathogenicity determines individual lifespan in Caenorhabditis elegans.

ABSTRACT: A common property of aging in all animals is that chronologically and genetically identical individuals age at different rates. To unveil mechanisms that influence aging variability, we identified markers of remaining lifespan for Caenorhabditis elegans. In transgenic lines, we expressed fluorescent reporter constructs from promoters of C. elegans genes whose expression change with age. The expression levels of aging markers in individual worms from a young synchronous population correlated with their remaining lifespan. We identified eight aging markers, with the superoxide dismutase gene sod-3 expression being the best single predictor of remaining lifespan. Correlation with remaining lifespan became stronger if expression from two aging markers was monitored simultaneously, accounting f

SUBMITTER: Sanchez-Blanco A 

PROVIDER: S-EPMC3077391 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature