Overnight closed loop insulin delivery (artificial pancreas) in adults with type 1 diabetes: crossover randomised controlled studies.

ABSTRACT:

Objective

To compare the safety and efficacy of overnight closed loop delivery of insulin (artificial pancreas) with conventional insulin pump therapy in adults with type 1 diabetes.

Design

Two sequential, open label, randomised controlled crossover, single centre studies.

Setting

Clinical research facility.

Participants

24 adults (10 men, 14 women) with type 1 diabetes, aged 18-65, who had used insulin pump therapy for at least three months: 12 were tested after consuming a medium sized meal and the other 12 after consuming a larger meal accompanied by alcohol.

Intervention

During overnight closed loop delivery, sensor measurements of glucose were fed into a computer algorithm, which advised on insulin pump infusion rates at 15 minute intervals. During

SUBMITTER: Hovorka R 

PROVIDER: S-EPMC3077739 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature