Association between SLC2A9 transporter gene variants and uric acid phenotypes in African American and white families.

ABSTRACT:

Objectives

SLC2A9 gene variants associate with serum uric acid in white populations, but little is known about African American populations. Since SLC2A9 is a transporter, gene variants may be expected to associate more closely with the fractional excretion of urate, a measure of renal tubular transport, than with serum uric acid, which is influenced by production and extrarenal clearance.

Methods

Genotypes of single nucleotide polymorphisms (SNPs) distributed across the SLC2A9 gene were obtained in the Genetic Epidemiology Network of Arteriopathy cohorts. The associations of SNPs with serum uric acid, fractional excretion of urate and urine urate-to-creatinine ratio were assessed with adjustments for age, sex, diuretic use, BMI, homocysteine and triglycerides.

Results

SUBMITTER: Rule AD 

PROVIDER: S-EPMC3077913 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature