MYADM regulates Rac1 targeting to ordered membranes required for cell spreading and migration.

ABSTRACT: Membrane organization into condensed domains or rafts provides molecular platforms for selective recruitment of proteins. Cell migration is a general process that requires spatiotemporal targeting of Rac1 to membrane rafts. The protein machinery responsible for making rafts competent to recruit Rac1 remains elusive. Some members of the MAL family of proteins are involved in specialized processes dependent on this type of membrane. Because condensed membrane domains are a general feature of the plasma membrane of all mammalian cells, we hypothesized that MAL family members with ubiquitous expression and plasma membrane distribution could be involved in the organization of membranes for cell migration. We show that myeloid-associated differentiation marker (MYADM), a protein with unique feat

SUBMITTER: Aranda JF 

PROVIDER: S-EPMC3078064 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature