Genetically determined Amerindian ancestry correlates with increased frequency of risk alleles for systemic lupus erythematosus.

ABSTRACT:

Objective

To assess whether genetically determined Amerindian ancestry predicts increased presence of risk alleles of known susceptibility genes for systemic lupus erythematosus (SLE).

Methods

Single-nucleotide polymorphisms (SNPs) within 16 confirmed genetic susceptibility loci for SLE were genotyped in a set of 804 Mestizo lupus patients and 667 Mestizo healthy controls. In addition, 347 admixture informative markers were genotyped. Individual ancestry proportions were determined using STRUCTURE. Association analysis was performed using PLINK, and correlation between ancestry and the presence of risk alleles was analyzed using linear regression.

Results

A meta-analysis of the genetic association of the 16 SNPs across populations showed that TNFSF4, STAT4, ITGAM, and

SUBMITTER: Sanchez E 

PROVIDER: S-EPMC3078084 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature