Adverse events post smallpox-vaccination: insights from tail scarification infection in mice with Vaccinia virus.

ABSTRACT: Adverse events upon smallpox vaccination with fully-replicative strains of Vaccinia virus (VACV) comprise an array of clinical manifestations that occur primarily in immunocompromised patients leading to significant host morbidity/mortality. The expansion of immune-suppressed populations and the possible release of Variola virus as a bioterrorist act have given rise to concerns over vaccination complications should more widespread vaccination be reinitiated. Our goal was to evaluate the components of the host immune system that are sufficient to prevent morbidity/mortality in a murine model of tail scarification, which mimics immunological and clinical features of smallpox vaccination in humans. Infection of C57BL/6 wild-type mice led to a strictly localized infection, with complete viral

SUBMITTER: Mota BE 

PROVIDER: S-EPMC3078145 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature