Innate immune genes synergize to predict increased risk of chronic disease in hepatitis C virus infection.

ABSTRACT: Hepatitis C is a common infection with significant morbidity and mortality, and only a minority of patients successfully clear the infection. Identification of factors that influence disease progression in HCV infection is difficult owing to the lack of well-defined patient cohorts. However, recent evidence supports a role for the innate immune system in virus clearance. In this study, we investigated innate immune genes for their contribution to disease progression in a unique cohort of well-controlled HCV-infected patients. The Irish cohort of HCV patients is uniquely homogenous; patients were infected with a single genotype of HCV from contaminated anti-D Ig. We genotyped 543 infected patients, including 247 patients who spontaneously resolved infection, for natural killer (NK) cell-ass

SUBMITTER: Dring MM 

PROVIDER: S-EPMC3078345 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature