Alterations in nucleolar structure and gene expression programs in prostatic neoplasia are driven by the MYC oncogene.

ABSTRACT: Increased nucleolar size and number are hallmark features of many cancers. In prostate cancer, nucleolar enlargement and increased numbers are some of the earliest morphological changes associated with development of premalignant prostate intraepithelial neoplasia (PIN) lesions and invasive adenocarcinomas. However, the molecular mechanisms that induce nucleolar alterations in PIN and prostate cancer remain largely unknown. We verify that activation of the MYC oncogene, which is overexpressed in most human PIN and prostatic adenocarcinomas, leads to formation of enlarged nucleoli and increased nucleolar number in prostate luminal epithelial cells in vivo. In prostate cancer cells in vitro, MYC expression is needed for maintenance of nucleolar number, and a nucleolar program of gene express

SUBMITTER: Koh CM 

PROVIDER: S-EPMC3078425 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature