Sex hormones and gene expression signatures in peripheral blood from postmenopausal women - the NOWAC postgenome study.

ABSTRACT:

Background

Postmenopausal hormone therapy (HT) influences endogenous hormone concentrations and increases the risk of breast cancer. Gene expression profiling may reveal the mechanisms behind this relationship.Our objective was to explore potential associations between sex hormones and gene expression in whole blood from a population-based, random sample of postmenopausal women

Methods

Gene expression, as measured by the Applied Biosystems microarray platform, was compared between hormone therapy (HT) users and non-users and between high and low hormone plasma concentrations using both gene-wise analysis and gene set analysis. Gene sets found to be associated with HT use were further analysed for enrichment in functional clusters and network predictions. The gene expression

SUBMITTER: Waaseth M 

PROVIDER: S-EPMC3078834 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature