Sponge non-metastatic Group I Nme gene/protein - structure and function is conserved from sponges to humans.

ABSTRACT:

Background

Nucleoside diphosphate kinases NDPK are evolutionarily conserved enzymes present in Bacteria, Archaea and Eukarya, with human Nme1 the most studied representative of the family and the first identified metastasis suppressor. Sponges (Porifera) are simple metazoans without tissues, closest to the common ancestor of all animals. They changed little during evolution and probably provide the best insight into the metazoan ancestor's genomic features. Recent studies show that sponges have a wide repertoire of genes many of which are involved in diseases in more complex metazoans. The original function of those genes and the way it has evolved in the animal lineage is largely unknown. Here we report new results on the metastasis suppressor gene/protein homolog from the marine

SUBMITTER: Perina D 

PROVIDER: S-EPMC3078890 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature