Ontology highlight
ABSTRACT:
SUBMITTER: Xu K
PROVIDER: S-EPMC3078994 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Developmental cell 20110310 4
Cardiovascular function depends on patent blood vessel formation by endothelial cells (ECs). However, the mechanisms underlying vascular "tubulogenesis" are only beginning to be unraveled. We show that endothelial tubulogenesis requires the Ras interacting protein 1, Rasip1, and its binding partner, the RhoGAP Arhgap29. Mice lacking Rasip1 fail to form patent lumens in all blood vessels, including the early endocardial tube. Rasipl null angioblasts fail to properly localize the polarity determin ...[more]