Ontology highlight
ABSTRACT:
SUBMITTER: Gule MK
PROVIDER: S-EPMC3079006 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Gule Maria K MK Chen Yunyun Y Sano Daisuke D Frederick Mitchell J MJ Zhou Ge G Zhao Mei M Milas Zvonimir L ZL Galer Chad E CE Henderson Ying C YC Jasser Samar A SA Schwartz David L DL Bankson James A JA Myers Jeffrey N JN Lai Stephen Y SY
Clinical cancer research : an official journal of the American Association for Cancer Research 20110110 8
<h4>Purpose</h4>Anaplastic thyroid carcinoma (ATC) is one of the most lethal human cancers with a median survival of 6 months. The inhibition of epidermal growth factor receptor (EGFR) alone, or with VEGF receptor 2 (VEGFR2), represents an attractive approach for treatment of ATC. Several reports have examined agents that target these receptors. However, with the misidentification of as many as 60% of all commonly used ATC cell lines, the significance of these past findings is unclear.<h4>Experi ...[more]