Scoring protein relationships in functional interaction networks predicted from sequence data.

ABSTRACT:

Unlabelled

The abundance of diverse biological data from various sources constitutes a rich source of knowledge, which has the power to advance our understanding of organisms. This requires computational methods in order to integrate and exploit these data effectively and elucidate local and genome wide functional connections between protein pairs, thus enabling functional inferences for uncharacterized proteins. These biological data are primarily in the form of sequences, which determine functions, although functional properties of a protein can often be predicted from just the domains it contains. Thus, protein sequences and domains can be used to predict protein pair-wise functional relationships, and thus contribute to the function prediction process of uncharacterized protein

SUBMITTER: Mazandu GK 

PROVIDER: S-EPMC3079720 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature