Microsomal monooxygenase as a multienzyme system: the role of P450-P450 interactions.

ABSTRACT:

Introduction

There is increasing evidence of physical interactions (association) among cytochromes P450 in the membranes of the endoplasmic reticulum. Functional consequences of these interactions are often underestimated.

Areas covered

This article provides a comprehensive overview of available experimental material regarding P450-P450 interactions. Special emphasis is given to the interactions between different P450 species and to the functional consequences of homo- and heterooligomerization.

Expert opinion

Recent advances provide conclusive evidence for a substantial degree of P450 oligomerization in membranes. Interactions between different P450 species resulting in the formation of mixed oligomers with altered activity and substrate specificity have been demonst

SUBMITTER: Davydov DR 

PROVIDER: S-EPMC3079778 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature