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Temporary disruption of fear-potentiated startle following PKM? inhibition in the amygdala.

ABSTRACT: We examined whether protein kinase M zeta (PKM?) inhibition in the amygdala permanently disrupts fear memory by testing retention at various intervals after PKM? blockade. Although the expression of fear memory was disrupted when the inhibitor was applied shortly before testing, it had no effect when rats were tested with longer retention intervals. These results suggest that PKM? inhibition does not erase memory, but temporarily disrupts expression of memory.

SUBMITTER: Parsons RG 

PROVIDER: S-EPMC3080103 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature

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Temporary disruption of fear-potentiated startle following PKMζ inhibition in the amygdala.

Parsons Ryan G RG   Davis Michael M  

Nature neuroscience 20110123 3

We examined whether protein kinase M zeta (PKMζ) inhibition in the amygdala permanently disrupts fear memory by testing retention at various intervals after PKMζ blockade. Although the expression of fear memory was disrupted when the inhibitor was applied shortly before testing, it had no effect when rats were tested with longer retention intervals. These results suggest that PKMζ inhibition does not erase memory, but temporarily disrupts expression of memory. ...[more]

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