Predictive integration of gene functional similarity and co-expression defines treatment response of endothelial progenitor cells.

ABSTRACT:

Background

Endothelial progenitor cells (EPCs) have been implicated in different processes crucial to vasculature repair, which may offer the basis for new therapeutic strategies in cardiovascular disease. Despite advances facilitated by functional genomics, there is a lack of systems-level understanding of treatment response mechanisms of EPCs. In this research we aimed to characterize the EPCs response to adenosine (Ado), a cardioprotective factor, based on the systems-level integration of gene expression data and prior functional knowledge. Specifically, we set out to identify novel biosignatures of Ado-treatment response in EPCs.

Results

The predictive integration of gene expression data and standardized functional similarity information enabled us to identify new treatm

SUBMITTER: Azuaje FJ 

PROVIDER: S-EPMC3080295 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature