Comparative transcriptome profiling of amyloid precursor protein family members in the adult cortex.

ABSTRACT:

Background

The β-amyloid precursor protein (APP) and the related β-amyloid precursor-like proteins (APLPs) undergo complex proteolytic processing giving rise to several fragments. Whereas it is well established that Aβ accumulation is a central trigger for Alzheimer's disease, the physiological role of APP family members and their diverse proteolytic products is still largely unknown. The secreted APPsα ectodomain has been shown to be involved in neuroprotection and synaptic plasticity. The γ-secretase-generated APP intracellular domain (AICD) functions as a transcriptional regulator in heterologous reporter assays although its role for endogenous gene regulation has remained controversial.

Results

To gain further insight into the molecular changes associated with knockout p

SUBMITTER: Aydin D 

PROVIDER: S-EPMC3080314 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature