Latexin expression is downregulated in human gastric carcinomas and exhibits tumor suppressor potential.

ABSTRACT:

Background

Latexin, also known as endogenous carboxypeptidase inhibitor (CPI), has been found to inhibit mouse stem cell populations and lymphoma cell proliferation, demonstrating its potential role as a tumor suppressor. Our previous study also suggested a correlation between latexin expression and malignant transformation of immortalized human gastric epithelial cells. Here, we examined latexin expression in human gastric carcinomas and investigated the effect of differential latexin expression on proliferation of gastric cancer cells in vitro and in vivo.

Methods

Monoclonal antibody against human latexin was prepared and immunohistochemical analysis was performed to detect latexin expression in 41 paired gastric carcinomas and adjacent normal control tissues. Human gastri

SUBMITTER: Li Y 

PROVIDER: S-EPMC3080345 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature