Characterization of a human cell line stably over-expressing the candidate oncogene, dual specificity phosphatase 12.

ABSTRACT:

Background

Analysis of chromosomal rearrangements within primary tumors has been influential in the identification of novel oncogenes. Identification of the "driver" gene(s) within cancer-derived amplicons is, however, hampered by the fact that most amplicons contain many gene products. Amplification of 1q21-1q23 is strongly associated with liposarcomas and microarray-based comparative genomic hybridization narrowed down the likely candidate oncogenes to two: the activating transcription factor 6 (atf6) and the dual specificity phosphatase 12 (dusp12). While atf6 is an established transcriptional regulator of the unfolded protein response, the potential role of dusp12 in cancer remains uncharacterized.

Methodology/principal findings

To evaluate the oncogenic potential of dus

SUBMITTER: Cain EL 

PROVIDER: S-EPMC3080379 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature