Modelling the protective efficacy of alternative delivery schedules for intermittent preventive treatment of malaria in infants and children.

ABSTRACT:

Background

Intermittent preventive treatment in infants (IPTi) with sulfadoxine-pyrimethamine (SP) is recommended by WHO where malaria incidence in infancy is high and SP resistance is low. The current delivery strategy is via routine Expanded Program on Immunisation contacts during infancy (EPI-IPTi). However, improvements to this approach may be possible where malaria transmission is seasonal, or where the malaria burden lies mainly outside infancy.

Methods and findings

A mathematical model was developed to estimate the protective efficacy (PE) of IPT against clinical malaria in children aged 2-24 months, using entomological and epidemiological data from an EPI-IPTi trial in Navrongo, Ghana to parameterise the model. The protection achieved by seasonally-targeted IPT in in

SUBMITTER: Cairns M 

PROVIDER: S-EPMC3080380 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature