SCN5A variation is associated with electrocardiographic traits in the Jackson Heart Study.

ABSTRACT:

Background

Understanding variation in the normal electric activity of the heart, assessed by the ECG, may provide a starting point for studies of susceptibility to serious arrhythmias such as sudden cardiac death during myocardial infarction or drug therapy. Recent genetic association studies of one ECG trait, the QT interval, have identified common variation in European-descent populations, but little is known about the genetic determinants of ECG traits in populations of African descent.

Methods and results

To identify genetic risk factors, we have undertaken a candidate gene study of ECG traits in collaboration with the Jackson Heart Study, a longitudinal study of 5301 blacks ascertained from the Jackson, Mississippi, area. Nine quantitative ECG traits were evaluated: P,

SUBMITTER: Jeff JM 

PROVIDER: S-EPMC3080430 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature