An efficient methodology to substituted furans via oxidation of functionalized α-diazo-β-ketoacetates.

ABSTRACT: DMDO oxidation of functionalized α-diazo-β-ketoacetates, formed by zinc triflate catalyzed Mukaiyama-aldol condensation of methyl diazoacetoacetate with aldehydes, occurred in quantitative yield to form dihydrofuranols that undergo acid catalyzed dehydration under mild conditions to generate 3-methoxyfuran-2-carboxylates in good yield.

SUBMITTER: Truong P 

PROVIDER: S-EPMC3080702 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature