Two common genetic variants near nuclear-encoded OXPHOS genes are associated with insulin secretion in vivo.

ABSTRACT:

Context

Mitochondrial ATP production is important in the regulation of glucose-stimulated insulin secretion. Genetic factors may modulate the capacity of the β-cells to secrete insulin and thereby contribute to the risk of type 2 diabetes.

Objective

The aim of this study was to identify genetic loci in or adjacent to nuclear-encoded genes of the oxidative phosphorylation (OXPHOS) pathway that are associated with insulin secretion in vivo.

Design and methods

To find polymorphisms associated with glucose-stimulated insulin secretion, data from a genome-wide association study (GWAS) of 1467 non-diabetic individuals, including the Diabetes Genetic Initiative (DGI), was examined. A total of 413 single nucleotide polymorphisms with a minor allele frequency ≥0.05 located in

SUBMITTER: Olsson AH 

PROVIDER: S-EPMC3080761 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature