Chromosomal radiosensitivity and acute radiation side effects after radiotherapy in tumour patients--a follow-up study.

ABSTRACT:

Background

Radiotherapists are highly interested in optimizing doses especially for patients who tend to suffer from side effects of radiotherapy (RT). It seems to be helpful to identify radiosensitive individuals before RT. Thus we examined aberrations in FISH painted chromosomes in in vitro irradiated blood samples of a group of patients suffering from breast cancer. In parallel, a follow-up of side effects in these patients was registered and compared to detected chromosome aberrations.

Methods

Blood samples (taken before radiotherapy) were irradiated in vitro with 3 Gy X-rays and analysed by FISH-painting to obtain aberration frequencies of first cycle metaphases for each patient. Aberration frequencies were analysed statistically to identify individuals with an elevated

SUBMITTER: Huber R 

PROVIDER: S-EPMC3080817 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature