Tahyna virus genetics, infectivity, and immunogenicity in mice and monkeys.

ABSTRACT:

Background

Tahyna virus (TAHV) is a human pathogen of the California encephalitis virus (CEV) serogroup (Bunyaviridae) endemic to Europe, Asia, and Africa. TAHV maintains an enzootic life cycle with several species of mosquito vectors and hares, rabbits, hedgehogs, and rodents serving as small mammal amplifying hosts. Human TAHV infection occurs in summer and early fall with symptoms of fever, headache, malaise, conjunctivitis, pharyngitis, and nausea. TAHV disease can progress to CNS involvement, although unlike related La Crosse virus (LACV), fatalities have not been reported. Human infections are frequent with neutralizing antibodies present in 60-80% of the elderly population in endemic areas.

Results

In order to determine the genomic sequence of wild-type TAHV, we chose

SUBMITTER: Bennett RS 

PROVIDER: S-EPMC3080826 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature