The CD4+ T-cell transcriptome and serum IgE in asthma: IL17RB and the role of sex.

ABSTRACT:

Background

The relationships between total serum IgE levels and gene expression patterns in peripheral blood CD4+ T cells (in all subjects and within each sex specifically) are not known.

Methods

Peripheral blood CD4+ T cells from 223 participants from the Childhood Asthma Management Program (CAMP) with simultaneous measurement of IgE. Total RNA was isolated, and expression profiles were generated with Illumina HumanRef8 v2 BeadChip arrays. Modeling of the relationship between genome-wide gene transcript levels and IgE levels was performed in all subjects, and stratified by sex.

Results

Among all subjects, significant evidence for association between gene transcript abundance and IgE was identified for a single gene, the interleukin 17 receptor B (IL17RB), explaining

SUBMITTER: Hunninghake GM 

PROVIDER: S-EPMC3080837 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature