Identification and functional validation of the novel antimalarial resistance locus PF10_0355 in Plasmodium falciparum.

ABSTRACT: The Plasmodium falciparum parasite's ability to adapt to environmental pressures, such as the human immune system and antimalarial drugs, makes malaria an enduring burden to public health. Understanding the genetic basis of these adaptations is critical to intervening successfully against malaria. To that end, we created a high-density genotyping array that assays over 17,000 single nucleotide polymorphisms (∼ 1 SNP/kb), and applied it to 57 culture-adapted parasites from three continents. We characterized genome-wide genetic diversity within and between populations and identified numerous loci with signals of natural selection, suggesting their role in recent adaptation. In addition, we performed a genome-wide association study (GWAS), searching for loci correlated with resistance to thir

SUBMITTER: Van Tyne D 

PROVIDER: S-EPMC3080868 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature