Artificially induced epithelial-mesenchymal transition in surgical subjects: its implications in clinical and basic cancer research.

ABSTRACT:

Background

Surgical samples have long been used as important subjects for cancer research. In accordance with an increase of neoadjuvant therapy, biopsy samples have recently become imperative for cancer transcriptome. On the other hand, both biopsy and surgical samples are available for expression profiling for predicting clinical outcome by adjuvant therapy; however, it is still unclear whether surgical sample expression profiles are useful for prediction via biopsy samples, because little has been done about comparative gene expression profiling between the two kinds of samples.

Methodology and findings

A total of 166 samples (77 biopsy and 89 surgical) of normal and malignant lesions of the esophagus were analyzed by microarrays. Gene expression profiles were compared be

SUBMITTER: Aoyagi K 

PROVIDER: S-EPMC3080870 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature