Many putative endocrine disruptors inhibit prostaglandin synthesis.

ABSTRACT:

Background

Prostaglandins (PGs) play key roles in development and maintenance of homeostasis of the adult body. Despite these important roles, it remains unclear whether the PG pathway is a target for endocrine disruption. However, several known endocrine-disrupting compounds (EDCs) share a high degree of structural similarity with mild analgesics.

Objectives and methods

Using cell-based transfection and transduction experiments, mass spectrometry, and organotypic assays together with molecular modeling, we investigated whether inhibition of the PG pathway by known EDCs could be a novel point of endocrine disruption.

Results

We found that many known EDCs inhibit the PG pathway in a mouse Sertoli cell line and in human primary mast cells. The EDCs also reduced PG synth

SUBMITTER: Kristensen DM 

PROVIDER: S-EPMC3080937 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature