Repulsive guidance molecule-A (RGM-A) inhibits leukocyte migration and mitigates inflammation.

ABSTRACT: Directed cell migration is a prerequisite not only for the development of the central nervous system, but also for topically restricted, appropriate immune responses. This is crucial for host defense and immune surveillance. Attracting environmental cues guiding leukocyte cell traffic are likely to be complemented by repulsive cues, which actively abolish cell migration. One such a paradigm exists in the developing nervous system, where neuronal migration and axonal path finding is balanced by chemoattractive and chemorepulsive cues, such as the neuronal repulsive guidance molecule-A (RGM-A). As expressed at the inflammatory site, the role of RGM-A within the immune response remains unclear. Here we report that RGM-A (i) is expressed by epithelium and leukocytes (granulocytes, monocytes, a

SUBMITTER: Mirakaj V 

PROVIDER: S-EPMC3080996 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature