Sex hormones are associated with right ventricular structure and function: The MESA-right ventricle study.

ABSTRACT:

Rationale

Sex hormones have effects on the left ventricle, but hormonal influences on the right ventricle (RV) are unknown.

Objectives

We hypothesized that sex hormones would be associated with RV morphology in a large cohort free of cardiovascular disease.

Methods

Sex hormones were measured by immunoassay and RV ejection fraction (RVEF), stroke volume (RVSV), mass, end-diastolic volume, and end-systolic volume (RVESV) were measured by cardiac magnetic resonance imaging in 1,957 men and 1,738 postmenopausal women. The relationship between each hormone and RV parameter was assessed by multivariate linear regression.

Measurements and main results

Higher estradiol levels were associated with higher RVEF (β per 1 ln[nmol/L], 0.88; 95% confidence interval [CI], 0.32

SUBMITTER: Ventetuolo CE 

PROVIDER: S-EPMC3081282 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature