A novel strategy to screen Bacillus Calmette-Guerin protein antigen recognized by γδ TCR.

ABSTRACT:

Background

Phosphoantigen was originally identified as the main γδ TCR-recognized antigen that could activate γδ T cells to promote immune protection against mycobacterial infection. However, new evidence shows that the γδ T cells activated by phosphoantigen can only provide partial immune protection against mycobacterial infection. In contrast, whole lysates of Mycobacterium could activate immune protection more potently, implying that other γδ TCR-recognized antigens that elicit protective immune responses. To date, only a few distinct mycobacterial antigens recognized by the γδ TCR have been characterized.

Methodology/principal findings

In the present study, we established a new approach to screen epitopes or protein antigens recognized by the γδ TCR using Bacillus Calmet

SUBMITTER: Xi X 

PROVIDER: S-EPMC3081299 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature