Activation of the transforming growth factor beta pathway in bacterial otitis media.

ABSTRACT:

Objectives

Granulation tissue is common in otitis media (OM), yet little is known about the signaling pathways in the formation of granulation tissue in response to infections. In this study, we sought to investigate the activation of the transforming growth factor beta (TGF-beta) signaling pathway in the formation of granulation tissue in response to middle ear pathogens.

Methods

Rat OM models were made by inoculating pneumococcus type 6A or nontypeable Haemophilus influenzae into the middle ear cavity or by obstructing the eustachian tube. Various pathway activities in the middle ear mucosa were analyzed with microarrays.

Results

The TGF-beta signaling pathway was highly regulated in the middle ear cleft with bacterial OM, but not in the ears with eustachian tube ob

SUBMITTER: Lee YW 

PROVIDER: S-EPMC3081620 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature