Serum lipid biomarkers and hepatic lipase gene associations with age-related macular degeneration.

ABSTRACT:

Objective

A genetic variant in the high-density lipoprotein (HDL) cholesterol pathway, hepatic lipase (LIPC), was discovered to be associated with advanced age-related macular degeneration (AMD) in a genome-wide association study. In this study, we evaluated whether LIPC is associated with serum lipids, and whether this gene and serum lipids are independently associated with AMD.

Design

Case-control study.

Participants

A total of 458 participants from the Progression Study of Macular Degeneration and the Age-Related Eye Disease Ancillary Biomarker Study, including 318 advanced AMD cases with either geographic atrophy (n = 123) or neovascular disease (n = 195) and 140 controls.

Methods

Participants were genotyped for 8 variants associated with AMD: 2 CFH variant

SUBMITTER: Reynolds R 

PROVIDER: S-EPMC3081670 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature