Paraoxonase 1 polymorphisms and ischemic stroke risk: A systematic review and meta-analysis.

ABSTRACT:

Purpose

Paraoxonase 1 (PON1) polymorphisms have been implicated as risk factors for coronary artery disease, but the results of genetic association studies on the related phenotype of ischemic stroke are inconclusive. We performed a meta-analysis of published studies investigating the association between ischemic stroke and two nonsynonymous PON1 polymorphisms, rs662 (p.Q192R) and rs854560 (p.L55M) in humans.

Methods

We searched multiple electronic databases through June 30, 2009 for eligible studies. In main analyses, we calculated allele-based odds ratios with random effects models. In secondary analyses, we examined dominant and recessive genetic models as well, and performed subgroup and sensitivity analyses.

Results

Regarding rs662, we identified 22 eligible stud

SUBMITTER: Dahabreh IJ 

PROVIDER: S-EPMC3081717 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature