Pre-corneal tear film thickness in humans measured with a novel technique.

ABSTRACT:

Purpose

The purpose of this work was to gather preliminary data in normals and dry eye subjects, using a new, non-invasive imaging platform to measure the thickness of pre-corneal tear film.

Methods

Human subjects were screened for dry eye and classified as dry or normal. Tear film thickness over the inferior paracentral cornea was measured using laser illumination and a complementary metal-oxide-semiconductor (CMOS) camera. A previously developed mathematical model was used to calculate the thickness of the tear film by applying the principle of spatial auto-correlation function (ACF).

Results

Mean tear film thickness values (±SD) were 3.05 μm (0.20) and 2.48 μm (0.32) on the initial visit for normals (n=18) and dry eye subjects (n=22), respectively, and were signifi

SUBMITTER: Azartash K 

PROVIDER: S-EPMC3081798 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature