Risk factors for non-adherence and loss to follow-up in a three-year clinical trial in Botswana.

ABSTRACT:

Background

Participant non-adherence and loss to follow-up can compromise the validity of clinical trial results. An assessment of these issues was made in a 3-year tuberculosis prevention trial among HIV-infected adults in Botswana.

Methods and findings

Between 11/2004-07/2006, 1995 participants were enrolled at eight public health clinics. They returned monthly to receive bottles of medication and were expected to take daily tablets of isoniazid or placebo for three years. Non-adherence was defined as refusing tablet ingestion but agreeing to quarterly physical examinations. Loss to follow-up was defined as not having returned for appointments in ≥60 days. Between 10/2008-04/2009, survey interviews were conducted with 83 participants identified as lost to follow-up and 127

SUBMITTER: Gust DA 

PROVIDER: S-EPMC3081815 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature