α-synuclein reactive antibodies as diagnostic biomarkers in blood sera of Parkinson's disease patients.

ABSTRACT:

Background

Auto-antibodies with specificity to self-antigens have been implicated in a wide variety of neurological diseases, including Parkinson's (PD) and Alzheimer's diseases, being sensitive indicators of neurodegeneration and focus for disease prevention. Of particular interest are the studies focused on the auto-immune responses to amyloidogenic proteins associated with diseases and their applications in therapeutic treatments such as vaccination with amyloid antigens and antibodies in PD, Alzheimer's disease and potentially other neurodegeneration ailments.

Methodology/principal findings

Generated auto-antibodies towards the major amyloidogenic protein involved in PD Lewy bodies--α-synuclein and its amyloid oligomers and fibrils were measured in the blood sera of earl

SUBMITTER: Yanamandra K 

PROVIDER: S-EPMC3081826 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature